MDV-3100 GMP Manufacturer Best 99% Purity Enzalutamide Powder Cost of Supplier CAS 915087-33-1 CAS NO.915087-33-1

English name: Enzalutamide

CAS number: 915087-33-1

Molecular formula: C21H16F4N4O2S

Molecular weight: 464.44

EINECS Number: 805-022-1

Melting point: 198-200°C

Density: 1.49

Storage conditions: -20°C

Solubility:Soluble in DMSO(>25mg/ml)

Form:solid

Acidity coefficient (pKa): 13.88±0.46 (Predicted)

Color: White to off-white

Enzalutamide (XTANDI, enzalutamide) is an oral androgen receptor antagonist, currently approved by clinical research and FDA (Food and Drug Administration), for the treatment of metastatic castration-resistant prostate cancer that progresses after chemotherapy. Treatment, that is, patients with prostate cancer whose tumors or cancer cells are still growing after chemotherapy, can prolong survival. The incidence of prostate cancer in the United States is very high, with nearly 240,000 new patients (the highest among all cancers) every year, and nearly 30,000 deaths every year (second only to lung cancer, breast cancer, and colorectal cancer). The incidence rate in China is relatively low. Enzalutamide is an androgen receptor inhibitor with a different target than cabazitaxel approved in 2010 and abiraterone approved in 2011. It can competitively inhibit the binding of androgen to the receptor and can Inhibits nuclear transport of the androgen receptor and the interaction of this receptor with DNA. In vitro studies have shown that enzalutamide can inhibit the proliferation of prostate cancer cells and induce their death. In mouse prostate cancer xenograft model experiments Enzalutamide can reduce tumor volume. The main metabolite of enzalutamide is N-desmethylenzalutamide, which shows similar inhibitory activity as enzalutamide in vitro. The recommended adult dose of this drug is daily 160mg, rapidly absorbed after taking the drug, the plasma concentration reaches the highest level within 0.5-3h, the average terminal half-life is 5.8d, the main metabolizing enzymes are CYP2C8 and CYP3A4, the drug should be avoided with strong CYP2C8 inhibitors (such as gemfibrozil, gemfibrozil) For combined use, if co-administration is required, the dose of enzalutamide should be reduced to 80 mg once daily.

Q1.Are you a manufacturer or a trading company
A1.Our company is a leading manufacturer specializing in trade and the development, production and marketing of pharmaceutical intermediates and apis for more than 10 years.
Q2.What about the quality of your products
A2.We value quality as life.We strictly control the quality of each process, established a perfect quality control system.
Q3.In the third quarter.What is your minimum order quantity
A3.Our minimum order quantity is 1 gram.
Q4.Fourth quarter.Can you provide free test samples
A4.Yes, we can provide 10g free samples for consumer test.
Q5.What is your delivery time
A5.Delivery takes 2-3 days, depending on the destination.
Q6.What about the mode of transportation
A6.For urgent and light orders, UPS, FedEx, DHL, EMS can be used;For heavier goods, we provide the method of air or sea transportation to consumers.
Q7.So far.How about the terms of payment
A7.We accept T/T,  Paypal, , money gram, etc.
 

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.