High Quality CAS 82571-53-7 Ozagrel CAS NO.82571-53-7

Ozagrel, clopidogrel, cilostazol, and aspirin enteric-coated tablets are currently commonly used platelet aggregation inhibitors in my country. They belong to the thromboxane cyclooxygenase (TXA2) inhibitor class of antithrombotic drugs. It was successfully developed by Ono Pharmaceutical Co., Ltd. and Kissei Pharmaceutical Industry Co., Ltd., and was approved for listing in Japan in 1988. At present, the main domestic manufacturers are Liaoning Dandong Medical Innovation Pharmaceutical Co., Ltd., Shandong Luoxin Pharmaceutical Co., Ltd., Changchun Jingyou Pharmaceutical Co., Ltd., Dalian Meruo Pharmaceutical Factory, Shenyang Jishi Pharmaceutical Co., Ltd., Hainan Bikai Pharmaceutical Co., Ltd., Changchun Haobang Pharmaceutical Co., Ltd. and Shandong Pharmaceutical Co., Ltd. Hualu Pharmaceuticals. Modern medicine has proved that platelets play an important role in the process of arteriosclerosis and thrombosis. Effective regulation of platelets can play a multiplier effect on diseases caused by vascular lumen stenosis, blood embolism and circulatory system occlusion. Currently, platelet aggregation inhibitor drugs in clinical use are mainly cyclooxygenase (TXA2) inhibitors, phosphodiesterase (PDE) inhibitors, adenosine diphosphate (ADP) receptor blockers, and platelet fibrinogen blockers. medicines, etc. The sodium salt of ozagrel has a powerful antithrombotic effect, and is the world's first marketed potent inhibitor of thromboxane synthase properties. It can inhibit the platelet aggregation caused by HT, etc. It can inhibit the TXA2 synthase and promote the generation of PGI2. It has the effect of anti-platelet aggregation and relieving vasospasm, and can inhibit the formation of cerebral thrombosis and cerebral vasospasm. It is mainly used for the improvement of cerebrovascular contracture and cerebral ischemia after subarachnoid hemorrhage. It can reduce fibrin and coagulation factor I in patients with cerebral infarction, has the effect of reducing blood viscosity, and inhibits platelet aggregation. In the brain doucet model test caused by the injection of arachidonic acid, it can inhibit the occurrence of cerebral thrombosis, reduce the mortality rate of animals, improve the movement disorder in the acute stage of cerebral thrombosis, and improve the circulation disorder and cerebral ischemia in the acute stage of cerebral ischemia. Improve abnormal energy metabolism in cerebral ischemia. The commonly used preparation is ozagrel sodium injection, each 20mg. After diluting with normal saline or glucose injection, intravenous infusion, 80 mg per day. If it is used in combination with other antiplatelet drugs, the dose of this product should be reduced appropriately. Bleeding tendencies may occur; occasional allergy, liver dysfunction, blood pressure drop, supraventricular extrasystole, headache, injection site pain, epigastric distention and other adverse reactions. Patients with hemorrhage (intracerebral hemorrhage, intraventricular hemorrhage, gastrointestinal hemorrhage, subcutaneous hemorrhage, etc.), pregnant or possibly pregnant women and children should use with caution. It has a synergistic effect with drugs that inhibit platelet function, and the dose must be appropriately reduced. Avoid mixing with calcium-containing solutions (Green's solution, etc.) to avoid turbidity.

English name: Ozagrel

CAS number: 82571-53-7

Molecular formula: C13H12N2O2

Molecular weight: 228.25

EINECS Number: 919-112-4

Melting point: 223-224°

Boiling point: 468.0±25.0 °C (Predicted)

Density: 1.17±0.1 g/cm3(Predicted)

Storage conditions:Sealed in dry,Room Temperature

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English name: Ozagrel
CAS number: 82571-53-7
Molecular formula: C13H12N2O2
Molecular weight: 228.25
EINECS Number: 919-112-4
Prismatic crystals are obtained from ethanol-ether, the melting point is 223~224℃. Ozagrel Hydrochloride: C13H12N2O2HCl. [78712-43-3]. Crystallized from ethanol-diethyl ether, melting point 214~217℃. Ozadrel Sodium: C13H11N2NaO2. White crystal or crystalline powder, odorless, sour and bitter taste. Soluble in water, soluble in methanol, almost insoluble in ethanol, acetone or ether. Acute toxicity LD50 male and female mice, male and female rats (mg/kg): 1940, 1580, 1150, 1300 intravenously; 3800.3600.5900, 5700 orally; 2450, 2100, 2300, 2250 subcutaneously.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

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An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


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