Red Yeast Rice Extract Lovastatin CAS No. 75330-75-5/Ethyl 4-Aminobenzoate 99% with Best Price CAS No. 94-09-7/95-20-5/2624-44-4 CAS NO.75330-75-5

Lovastatin is a hexahydronaphthyl ester isolated from the culture solution of Aspergillus terreus. It is an inactive lactone. It is only active after being hydrolyzed after oral administration. It has a strong competitive inhibitory effect on HMG-CoA reductase in the liver. HMG-CoA reductase is the rate-limiting enzyme for de novo cholesterol synthesis in the body. The inhibition of this enzyme can block the conversion of HMG-CoA to methylvaleric acid, significantly reduce cholesterol synthesis, increase the expression of LDL receptors in the liver, and reduce plasma LDL. -C's scavenging enhancement. Decreased cholesterol synthesis can also reduce liver synthesis of ApoB100, thereby reducing VLDL synthesis. Clinical observations show that this product has a good effect on reducing plasma total cholesterol and LDLC regardless of hypercholesterolemia caused by various causes such as heterozygous familial hypercholesterolemia, polygenic hypercholesterolemia, diabetes or nephrotic syndrome. effect. Statins are secondary metabolites of filamentous fungi that selectively inhibit hydroxymethylglutarate coenzyme A (HMG-CoA) reductase activity and block cholesterol biosynthesis, which is consistent with the acid structure of statins and HMG -CoA is similar. Currently, such drugs (statins, statins) used in humans mainly include natural statins and synthetic statins. Natural statins include lovastatin, mevastatin, pravastatin and simvastatin, lovastatin is produced by fermentation of Aspergillus terreus, and mevastatin is produced by Penicillium citrinum ( penicillium citrinum) was obtained by the transformation of streptomyces carbophilus after fermentation, and simvastatin was produced from lovastatin by semi-synthesis (chemical modification of the side chain). Synthetic statins include fluvastatin, cerivastatin and atorvastatin.

1. Lipid-regulating effect Lovastatin blocks endogenous cholesterol synthesis by inhibiting the rate-limiting enzyme HMG-CoA reductase of cholesterol synthesis, reduces intracellular cholesterol content, and feedback increases the number of LDL receptors on the cell surface , accelerates the uptake and degradation of LDL particles in the blood circulation, and reduces total cholesterol and very low density lipoprotein (VLDL), LDL and triglycerides in plasma. Since the conversion of HMG-CoA to mevalonate is an early step in the cholesterol biosynthesis pathway, the use of lovastatin does not result in the accumulation of potentially toxic cholesterol substances, and HMG-CoA can also be rapidly reversely metabolized to acetyl-CoA , participates in other biosynthetic pathways in the body, this inhibitory effect is incomplete and reversible, there is a dose-effect relationship, and the amount of cholesterol required for the normal function of the cell membrane will not be affected under the therapeutic dose. Therefore, lovastatin has a significant effect. Blood lipid lowering effect and less side effects. In general, lovastatin mainly exerts its effects from the following aspects: ① competitive inhibition of HMG-CoA reductase activity, reducing endogenous cholesterol synthesis; ② increasing the expression of LDL receptors in hepatocytes and increasing receptor-mediated The clearance rate of plasma LDL; ③ inhibit the migration and proliferation of smooth muscle cells; ④ reduce the assembly and secretion of hepatic lipoprotein. 2. Non-lipid-regulating effect Lovastatin can significantly improve the function of endothelial cells, promote the production of nitric oxide synthase (eNOS), and thus increase the synthesis and release of NO, in addition to its significant hypolipidemic effect. Maintaining normal human pulmonary vascular tone and reversing hypoxia-induced pulmonary vasoconstriction and vascular remodeling are critical. In addition, lovastatin has anti-inflammatory and anti-proliferative effects, and can inhibit the proliferation of renal mesangial cells and the secretion of extracellular matrix, thereby reducing glomerulosclerosis.

1. We has 11 years' exporting experience in pharmaceutical ingredient products.

Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

1. A novel blood lipid regulating drug-HMG-CoA (β-hydroxy, β-methyl-glutaryl coenzyme A) reductase inhibitor. It can significantly reduce the concentration of serum total cholesterol. After oral administration, it is hydrolyzed into the corresponding β-hydroxy acid, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and inhibits cholesterol synthesis. It is clinically used for heterozygous familial hypercholesterolemia, severe and mild primary hypercholesterolemia, and can also be used as an adjunct drug for diet therapy to reduce excessive cholesterol and low-density protein cholesterol levels.

2. Medication for the cardiovascular system can prevent the development of arteriosclerosis and reduce the risk of myocardial infarction.

3. A cholesterol-lowering drug and a competitive inhibitor of HMG-CoA reductase, a rate-limiting enzyme for cholesterol synthesis. Blocks the production of mevalonate, a key compound in cholesterol and isoprene production. This product is a substrate for Pgp and CYP3A. It increases cellular resistance to anticancer drugs, such as doxorubicin, and induces apoptosis in myeloma cells. The product induces apoptosis in numerous cancer cells, in part by inhibiting Rho family GTPases. It causes the cell cycle to be trapped in G1 and G2/M phases

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.

Chemical NameMelanotan II acetate salt
Synonyms(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide;
CAS No.121062-08-6
Molecular FormulaC50H69N15O9
Molecular Weight1024.18000
PSA382.26000
LogP3.60720
Appearance & Physical Statesolid
Density1.43 g/cm3
Refractive Index1.669
Storage Condition-20oC