Leuprolide acetate Anti-Cancer Peptide Acetate/ Leuprorelin acetate CAS 74381-53-6 CAS NO.74381-53-6

English name: Leuprorelin acetate

CAS number: 74381-53-6

Molecular formula: C61H88N16O14

Molecular weight: 1269.47

EINECS Number: 686-285-8

Melting point: 150-155°C

Storage conditions: -20°C

Solubility: DMSO (Slightly), Methanol (Slightly)

Form:Solid

Color: White to Off-White

Leuprorelin acetate (Leuprorelin/Leuprolideacetate, LA) is a synthetic water-soluble nonapeptide closed at both ends, and its amino acid sequence is 5-oxo-L-prolyl-L-histidyl-L-tryptophanyl -L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide monoacetate, with a molecular weight of 1269.47, Soluble in water, ethanol and propylene glycol, pKa6.9.

Leuprolide acetate is a commonly used hormone anticancer drug. It is the acetate salt of leuprolide, a synthetic nonapeptide analog of gonadotropin-releasing hormone (LHRH, a decapeptide). It belongs to LH-RH. Antagonist, LHRH is produced by the hypothalamus, which can induce the anterior pituitary to release gonadotropins and follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Due to its similar structure to LHRH, this product also has the function of promoting the release of FSH and LH after acting on the anterior pituitary, thereby increasing the serum concentration of testosterone and dihydrotestosterone. It is clinically used for maintenance treatment of advanced prostate cancer, but after about 1 week of application of this product, the number of active receptors will decrease, and the secretion of gonadotropins will also decrease. After 2 to 4 weeks, testosterone and dihydrotestosterone concentrations can be reduced to castration levels. When the drug is discontinued, gonadotropins and androgens can return to normal concentrations. It should be noted that oral administration of this product is ineffective, and subcutaneous or intramuscular injection is well absorbed. T1/2 for parenteral administration is 3h. There is no accumulation in the body, and the excretion rates of the original drug and metabolites in the urine are 2.9% and 1.5%, respectively. Ethanol can enhance the effect of this product, and it is not advisable to drink alcohol during the treatment, so as to avoid the occurrence of adverse reactions that are difficult to control. During the first week of treatment, hospitalization should be performed as much as possible for monitoring, and experienced physicians should be selected to guide medication to prevent serious neurological complications and urethral obstruction. The injection site should be changed frequently.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.