Pirarubicin CAS 72496-41-4 CAS NO.72496-41-4

Pirarubicin is a new anthracycline anticancer agent structurally related to doxorubicin. In acute leukemia, non-Hodgkin's lymphoma, breast and ovariail carcinoma, pirarubicin is reportedly superior to doxorubicin and better tolerated. Its major side-effect appears to be myelosuppression, mainly in the form of leucopenia, which is potentially dose-limiting.

Pirarubicin is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.

Indications
Suitable for the treatment of breast cancer, head and neck cancer, bladder cancer, ureter cancer, renal pelvis cancer, ovarian cancer, cervical cancer and other malignant tumors also have a certain effect.

What is Pirarubicin

Doxorubicin pyranohydrin is an anthracycline cell cycle non - specific antitumor agent. This drug can be directly embedded into the DNA double strand, inhibit DNA polymerase, prevent nucleic acid synthesis, and prevent cell division in G2 phase, resulting in the death of tumor cells. The drug is also effective for adriamycin - resistant patients.

Function of Pirarubicin

Suitable for the treatment of breast cancer, head and neck cancer, bladder cancer, ureter cancer, renal pelvis cancer, ovarian cancer, cervical cancer and other malignant tumors also have a certain effect

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

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3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
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Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
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Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.

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Chemical Name Pirarubicin
Synonyms(8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; Pinorubicin; Therarubicin;
CAS Number 72496-41-4
Molecular Formula C32H37NO12
Appearance Orange to Red Solid
Melting Point>175°C (dec.)
Molecular Weight 627.64
StorageHygroscopic, -20C Freezer, Under Inert Atmosphere
SolubilityChloroform (Slightly), Meth (Slightly, Heated)
StabilityHygroscopic
CategoryStandards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsStructural analog of Doxorubicin. Antineoplastic.
ReferencesUmezawa, H., et al.: J. Antibiot., 32, 1082 (1979), Majima, H., et al.: Biomed. Pharmacother., 41, 237 (1987), Miller, A.A., et al.: Cancer Res., 47, 1461 (1987), Fallik, D., et al.: Ann. Ocol., 14, 856 (2003),