Bulk Supply Nice Price Bilirubin 99% CAS 635-65-4 Bilirubin Powder CAS NO.635-65-4

English name: Bilirubin

CAS Number: 635-65-4

Molecular formula: C33H36N4O6

Molecular weight: 584.66

EINECS Number: 211-239-7

Melting point: 192°C

Boiling point: 641.7°C (rough estimate)

Density: 1.2163 (rough estimate)

Refractive index: 1.6000 (estimate)

Storage conditions: -20°C

Solubility:aqueousacid:soluble

Acidity coefficient: (pKa) 4.62±0.10 (Predicted)

Form: powder

Color: orange

Water solubility:practically in soluble

Sensitivity: Light Sensiti

In addition to natural bilirubin IXα, it also contains III{α and XIII{α isomers. In the IX{α molecule, the two vinyl groups on the pyrrole ring are in the inner position and the outer position, respectively. Under acidic conditions, the isomer III{α or the isomer with both vinyl groups in the outer position can be formed. Body XIII{α. In the production process, the type, concentration and operation of acid used in acidification are different, and the degree of isomerization is also different. This product is mainly derived from the reduction product of heme in hemoglobin through a series of catabolism after the disintegration of senescent red blood cells. It is golden yellow or dark reddish brown monoclinic crystal, odorless and tasteless. It is soluble in organic solvents such as benzene, chloroform and carbon disulfide; it can also be dissolved in a mixture of hot ethanol and chloroform; sodium salts are easily soluble in water, but calcium salts, magnesium salts and barium salts are insoluble in water. Dry solid is more stable; chloroform solution is also more stable in the dark; it is unstable in alkaline solution (such as 0.1mmol/L sodium hydroxide) or in the presence of ferric ions, and is quickly oxidized to biliverdin, biliverdin It can be reduced to bilirubin by in vitro chemical reactions or by biliverdin reductase. Bilirubin can bind to glycine, alanine or histidine. Bilirubin is a strong endogenous antioxidant at normal serum concentrations. The molecular structure of bilirubin can have two types: ketone and alcohol. Because bilirubin exhibits a specific coiled structure, the hydrophobicity is increased, and it can enter the interior of lipid molecules. Bilirubin has an extended conjugated double bond system and active hydrogen atoms that prevent oxidation. Experiments show that bilirubin can inhibit the oxidative modification of LDL (low-density lipoprotein in blood) to a certain extent in vitro, which can inhibit and alleviate the formation of atherosclerosis caused by LDL oxidative modification. The purpose of the treatment of coronary heart disease.

1. Bilirubin has a variety of pharmacological effects and is the main raw material for the manufacture of artificial bezoar. Pharmacological experiments have shown that it has a good inhibitory effect on W256 tumor, and the inactivation rate and inhibition index of Japanese encephalitis virus are 1-1.5 times higher than those of deoxycholic acid and cholic acid; it is also an effective liver disease. It has the effect of proliferating new cells without destroying liver tissue, and can treat diseases such as serum hepatitis and liver cirrhosis. In addition, bilirubin has sedative, sedative, antipyretic, antihypertensive, and red blood cell Newborn etc. 2. For the determination of bilirubin in artificial bezoar, preparation and biochemical research of artificial bezoar. 3. Bilirubin has a variety of pharmacological effects and is the main raw material for the manufacture of artificial bezoar. Pharmacological experiments have shown that it has a good inhibitory effect on W256 tumor, and the inactivation rate and inhibition index of Japanese encephalitis virus are 1-1.5 times higher than those of deoxycholic acid and cholic acid; it is also an effective liver disease. Bilirubin has the effect of proliferating new cells without destroying liver tissue, and can treat diseases such as serum hepatitis and liver cirrhosis. In addition, bilirubin has sedative, sedative, antipyretic, and antihypertensive properties. Promote red blood cell regeneration and so on. 4. Uses: Biochemical research. analytical chemistry. Biochemical Research. Synthetic bezoar. Antioxidant, protects membrane phospholipids from oxidation by hydrogen peroxide free radicals. Protects neurons from oxidative damage even at nanomolar concentrations 5. A main component of heme decomposition; the main pigment of bile; has the function of antioxidant and effective hydrogen peroxide group scavenger, protects cell membrane lipids from the oxidation of these active groups 6. Antioxidant, protects membrane phospholipids from oxidation by hydrogen peroxide free radicals.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

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Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.