Assay 99% Manufacturer and Supply Pharmaceutical Powder Methazolamide CAS 554-57-4 CAS NO.554-57-4

English name: Methazolamide

CAS Number: 554-57-4

Molecular formula: C5H8N4O3S2

Molecular weight: 236.27

EINECS No.: 209-066-7

Melting point: 208°C(dec.)(lit.)

Boiling point: 402.0±28.0°C (Predicted)

Density: 1.6625 (rough estimate)

Refractive index: 1.6270 (estimate)

Storage conditions: 2-8°C

Solubility: DMSO:soluble20mg/mL,clear

Form: White powder

Acidity coefficient (pKa): 7.30(at25℃)

Color: white to beige

Water solubility: 2.835g/L (25ºC)

Methazolamide is also a carbonic anhydrase inhibitor and is mainly used in the treatment of glaucoma. It is a homologue of acetazolamide, and its chemical structure is similar to acetazolamide (one more methyl group on the nitrogen atom). Therefore, its pharmacological action and mechanism of action are the same as those of acetazolamide. The difference in structure reduces ionization, so the intraocular permeability is enhanced compared with acetazolamide. The effect of this product to penetrate the blood-aqueous humor and blood-brain barrier is also stronger than that of acetazolamide (the concentration of human cerebrospinal fluid is 50 times higher than that of acetazolamide). The inhibitory effect of carbonic anhydrase is 60% stronger than that of acetazolamide, and only 55% of methazolamide is bound to plasma proteins in the body, so lower doses have obvious ocular hypotensive reactions.

For primary open-angle glaucoma, angle-closure glaucoma and some secondary glaucoma, and the adjuvant treatment of patients with unsatisfactory intraocular pressure control with topical anti-glaucoma drugs. Because this product lowers intraocular pressure and has less effect on acid-base balance, it is better than acetazolamide for patients with severe obstructive pulmonary disease. The effect on urinary citrate secretion is smaller than that of acetazolamide, so methazolamide is recommended for patients who need oral carbonic anhydrase inhibitor treatment but are prone to kidney stone formation.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.