Supply Musk Extract Muscone 98% HPLC CAS 541-91-3 CAS NO.541-91-3

Chemical Name: Muscone
CAS No.: 541-91-3

Chemical Structure: C16H30O

Molecular weight: 238.41

Appearance: Colorless oil

Assay: 98%min

 

Matrine is an alkaloid found in plants from the genus Sophora. It has a variety of pharmacological effects, including anti-cancer effects,as well as κ-opioid and μ-opioid receptor agonism.

Matrine is a low-toxic plant-derived insecticide. Once the pest is touched, the nerve center is paralyzed, and then the body protein is solidified, the body pores are blocked, and the pest suffocates to death.

Function

Has a role in the expansion of the coronary arteries and increase coronary blood flow, has a certain effect on angina. Usually ships within 5 minutes after the medication (sublingual, inhalation) effective to alleviate the effect of angina and nitroglycerin slightly similar. Is one of the active ingredients obtained by distillation from a Cervidae forest musk deer Mosochus Bersxoxskii Fleror or original the musk deer Mo-SchumoschiferusL mature males Sachet dried secretions musk, scientific name - methyl cyclopentadecanone musk fragrance ingredients. Oily liquid, with special smell. Aromatic resuscitation, through the meridians, swelling and pain the role of The small dose excitatory effects on the central nervous, high-dose inhibition. Excitatory effect on isolated frog heart, and the male hormone-like effects and anti-inflammatory effects. Clinically for angina pectoris, vascular headache, sciatica, vitiligo. This product is domestic synthetic production. The pharmacological effects of synthetic products, similar to the trial, and natural musk ketone.  
 

Application
 

1.Muscone used for the preparation of flavor.

2.Muscone is widely used in cosmetic , perfume and fragrance industry, other daily-used products as fixative , essence for soap and cosmetics.

English name: Muscone

CAS Number: 541-91-3

Molecular formula: C16H30O

Molecular weight: 238.41

EINECS Number: 208-795-8

Melting point: -15°C(lit.)

Boiling point: 95°C/0.1mmHg(lit.)

Density: 0.9221FEMA3434|3-METHYL-1-CYCLOPENTADECANONE

Refractive index: 1.4770 to 1.4810 TECS No.: GY0950000

Storage conditions: Sealed in dry, RoomTemperature

Solubility: Chloroform, Methanol (Sparingly)

Form: Colorless oil.

Color: Colourless

Musk ketone has the functions of fragrant opening, clearing the meridians, reducing swelling and relieving pain. Small doses have excitatory effects on the central nervous system, while large doses have inhibitory effects. It has excitatory effect on isolated frog heart, and has male hormone-like effect and anti-inflammatory effect. Clinically used for coronary heart disease angina pectoris, vascular headache, sciatica, vitiligo, etc. This product has been synthesized and produced in China, and the pharmacological effect of the synthetic product is similar to that of natural musk ketone after testing. Multiple oral administration (5mg/kg) in rats can significantly shorten the sleep time caused by pentobarbital sodium. Destruction due to inactivation. Its pharmacological effects are as follows: anti-dementia studies have shown that musk ketone can significantly promote the uptake of calcium ions in the thoracic aorta of scopolamine-induced dementia model rats, and increase the intracellular availability of calcium by promoting calcium influx. Purpose. It has significant curative effect on senile dementia caused by intracellular availability of calcium lower than the physiological level; it can increase serum superoxide dismutase (SOD) activity and reduce brain tissue malondialdehyde (MAO) activity in aging model mice At the same time, it can improve the learning and memory function of dementia mice, and exert its anti-dementia effect by removing excess free radicals; inhibit the decomposition of monoamine transmitters in the brain, delay the brain neurotransmitter disorder caused by dementia, and improve the function of the central nervous system , which has a puzzle effect. Anti-cerebral ischemia musk ketone has a significant protective effect on hypoxia, hypoglycemia and reoxygenation injury of neuroblastoma cells, suggesting that musk ketone may be used for the treatment of acute stroke; it can significantly reduce the cerebral ischemia-reperfusion injury model Cerebral infarct volume in rats, attenuates nerve cell damage involved in cerebral ischemia-reperfusion. Anti-inflammatory musk ketone can inhibit interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), epoxy Synthase-2 (COX-2), inhibitory nitric oxide synthase (iNOS), nitric oxide (NO), production of matrix metalloproteinase 13, extracellular signal-regulated kinase (ERK1/2) and c-Jun Nitrogen-terminal kinase (JNK) signaling pathway has a significant inhibitory effect. Anti-myocardial ischemia musk ketone can significantly prolong the survival time of myocardial ischemia model rats caused by coronary artery ligation, increase coronary flow, reduce T wave peak and creatine kinase (CK) and LDH content, and has an effect on myocardial ischemia and angina pectoris. It can improve myocardial ischemia by reducing the release of plasma endothelin (ET), increasing the content of calcitonin gene-related peptide (CGRP), and increasing the expression of myocardial vascular endothelial growth factor (VEGF). protective effect. The inhibition rate of antitumor musk ketone on Ehrlich ascites tumor and leukocyte respiration in mice is higher than that in normal mice; it has destructive effect on isolated animal cancer cells, and has obvious inhibitory effect on the cellular respiration of animal tumor tissue; The effect of promoting Qi, promoting blood circulation and removing blood stasis, improving the hypercoagulable state of blood, reducing platelet adhesion and aggregation, improving fibrin content, increasing fibrinolysis and blood flow, improving the hypoxia state of tumor cell microenvironment, and reducing HIF-1 The expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor (bFGF) decreased, thereby inhibiting tumor angiogenesis. Effects on the central nervous system Musk ketone has a certain effect on the conditioned reflex of animals, and it varies with the dose. Rats were given musk ketone 5mg/kg by gavage, which can significantly shorten the sleep time caused by sodium pentobital, but large doses (100-500mg/kg) can prolong the sleep time. Excitatory effect, a large amount can also be inhibited. Anti-early pregnancy and anti-implantation natural musk has obvious excitatory effects on the isolated uterus of pregnant rats, rabbits or guinea pigs after abortion. It can gradually increase the uterine contractility and the rhythm, and has a more obvious effect on the uterus of rabbits in the late pregnancy. Therefore, traditional Chinese medicine has always regarded musk as a contraindication drug for pregnancy. Synthetic musk ketone has similar effects. Daily subcutaneous injection of musk ketone 20mg in mice can cause anti-implantation and anti-early pregnancy effects, and the longer the pregnancy period, the stronger the anti-pregnancy effect. In addition, musk ketone has anticoagulant, anti-inflammatory, antibacterial and antiulcer effects.

1. It has the effect of dilating coronary arteries and increasing coronary blood flow, and has a certain effect on angina pectoris. Generally, it takes effect within 5 minutes after administration (sublingual administration, aerosol inhalation), and the effect of relieving angina pectoris is slightly similar to that of nitroglycerin.

2. Musk ketone is a representative variety of macrocyclic musk. The basic chemical structure of macrocyclic musk is 13-19 acyclic and contains at least one functional group. According to the chemical structure, it can be divided into cyclic esters, cyclic lactones, cyclic oxygenated Ketones, cyclic ketolides, etc. Among the musk-type synthetic fragrances, the output of macrocyclic musk accounts for 5%. Musk ketone has a sweet and strong fragrance, which can be well blended with various spices. The aroma threshold is very low (0.001ppm-0.01ppm), and the fragrance lasts for a long time. It is an extremely effective fixative. Pharmacologically, it has the functions of invigorating the central nervous system, respiratory center and heart, and promoting the secretion of various urea bodies in drought disasters. It is an important drug for the treatment of confusion. It can protect the coronary arteries, increase coronary flow, and play a role in promoting blood circulation, reducing swelling and relieving pain. In addition, it has the effect of exciting the uterus and enhancing the contraction of uterine smooth muscle, so pregnant women should not use it. Musk is known for its ability to open orifices, open meridians, penetrate muscles and bones, internally treat stroke, middle qi, middle evil and children's convulsions, and externally treat iron damage and sore diseases. The addition of musk to advanced painting and calligraphy is not only elegant and fragrant, but also has the special effect of making the painting and calligraphy durable for a long time, not changing with water, and preventing corrosion.

3. For medicine, musk spice, fixative, etc.

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