99% Chemical Powder CAS 53-03-2 Prednisone CAS NO.53-03-2

English name: Prednisone

CAS number: 53-03-2

Molecular formula: C21H26O5

Molecular weight: 358.43

EINECS No.: 200-160-3

Melting point: 236-238°C(lit.)

Specific rotation: 169º (c=0.5, dioxane)

Boiling point: 410.86°C (rough estimate)

Density: 1.1121 (rough estimate)

Refractive index: 170°(C=0.5, Dioxane)

Flash point:>200℃

Storage conditions: 2-8°C

Prednisonum (PS) is an adrenal cortical hormone drug with anti-inflammatory and anti-allergic effects, which can inhibit the proliferation of connective tissue, reduce the permeability of capillary walls such as cell membranes, reduce inflammatory exudation, and reduce inflammatory exudation. It can inhibit the formation and release of histamine and other toxic substances. Prednisone is suitable for the treatment of connective tissue disease, systemic lupus erythematosus, severe bronchial asthma, dermatomyositis, vasculitis and other allergic diseases, acute leukemia, malignant lymphoma and other diseases.

Acetate is a white or almost white crystalline powder, odorless and bitter in taste. Insoluble in water, soluble in chloroform, slightly soluble in acetone, slightly soluble in ethanol or ethyl acetate.

This product is a medium-acting glucocorticoid drug. Has the following effects:

1. Anti-inflammatory effect can inhibit various inflammatory reactions, reduce the permeability of capillaries, inhibit the movement of inflammatory cells to the site of inflammation, prevent the response of inflammatory mediators, inhibit the function of phagocytes, stabilize the lysosomal membrane, and prevent complement from participating in the inflammatory response , inhibit the repair of post-inflammatory tissue damage, etc.

2. Inhibition of immunity can inhibit the phagocytic function of macrophages and prevent the effect of the mononuclear macrophage system to eliminate particles or cells; it can dissolve lymphocytes, resulting in the depletion of lymphocytes in lymph nodes, spleen and thymus, which is more obvious for T cells , among which the decrease in helper T cells was more significant. Autoimmune antibody levels can also be reduced.

3. Antitoxin can improve the stress ability of the body to harmful stimuli, reduce the damage of bacterial endotoxin to the body, relieve the symptoms of toxemia, and also reduce the release of internal pyrogens, which has an antipyretic effect on high fever infected with toxemia.

4. Anti-shock exerts anti-shock effect by increasing circulating blood volume, improving circulating perfusion, stabilizing lysosomal membrane, preventing lysosomal enzyme release, etc. Shock is effective.

5. The effect on metabolism can increase liver glycogen, increase blood sugar; improve the decomposition of protein Metabolism, and changes the distribution of body fat, forming central obesity. It can enhance the reabsorption of Na+ and the excretion of K+, Ca2+, P3-, but weaker than mineralocorticoids.

6. The effect on the blood and hematopoietic system can increase the number of red blood cells and platelets, and reduce the eosinophils and lymphocytes in the blood. And by increasing the concentration of fibrinogen, the clotting time is shortened.

7. The effect on the central nervous system increases its excitability, which can cause euphoria, agitation, insomnia, individual patients can induce mental disorders, and large doses in children can cause convulsions. 8. Others reduce the proliferation of connective tissue; promote the secretion of gastric acid and pepsin, and increase appetite. It is completely absorbed orally, and the bioavailability is about 80%. This product must be reduced to prednisone in the liver to show pharmacological activity.

Prednisonum (PS) is an adrenal cortical hormone drug with anti-inflammatory and anti-allergic effects, which can inhibit the proliferation of connective tissue, reduce the permeability of capillary walls such as cell membranes, reduce inflammatory exudation, and reduce inflammatory exudation. It can inhibit the formation and release of histamine and other toxic substances. Prednisone is suitable for the treatment of connective tissue disease, systemic lupus erythematosus, severe bronchial asthma, dermatomyositis, vasculitis and other allergic diseases, acute leukemia, malignant lymphoma and other diseases.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.