99% EP Grade Anti-inflammatory CAS 51333-22-3 Budesonide CAS NO.51333-22-3

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.

1, We offer competitive factory price for both wholesalers and retailers.
2, Fast reply for inquiries.
3, Stable Quality, high purity.
4, We offer EXW/FOB/CFR/DAP/DDP trade terms for your option.
5, Fast Delivery for shipment and Safe for destination custom clearance.
6, Free samples.
7, Free custom clearance with freight prepaid, delivery door to door.
8, More than 22 years export experience in this field.

Budesonide is a commonly used clinical drug for the treatment of bronchial asthma, and can be used for non-hormone-dependent or hormone-dependent asthma and asthmatic chronic bronchitis patients. For the treatment of seasonal or perennial allergic rhinitis and the prevention of polyp regeneration after nasal polyp removal. It can also be used to treat various skin diseases. Budesonide is a topical halogen-free adrenocortical hormone drug with significant anti-inflammatory, anti-allergic, antipruritic and anti-exudative effects. Its local action is the same as that of beclomethasone dipropionate, and it is mainly suitable for bronchial asthma that has not been well controlled by bronchodilators or antiallergic drugs in the past.

English name: Budesonide

CAS number: 51333-22-3

Molecular formula: C25H34O6

Molecular weight: 430.53

EINECS Number: 257-139-7

Melting point: 221-232°C (dec.)

Boiling point: 464.79°C (roughestimate)

Specific rotation: D25+98.9°(c=0.28inmethylenechloride)

Density: 1.1046 (roughestimate)

Refractive index: 1.4593 (estimate)

Storage condition:Store at RT

1. Induce the synthesis of lipocortin and inhibit phospholipase A2, reduce the production and release of platelet activating factor, leukotrienes, prostaglandins and other lipid inflammatory mediators generated by the enzyme catalyzed hydrolysis of membrane phospholipids. 2. Induce the expression of angiotensin I converting enzyme and neutral endopeptidase, respectively accelerate the generation of angiotensin II, and the degradation and inactivation of bradykinin and tachykinin; inhibit nitrous oxide synthase expression, reducing the production of nitrous oxide. Thereby constricting blood vessels, or reducing the effects of dilating blood vessels, causing inflammation and inducing neurogenic inflammatory responses of various active substances except angiotensin II. In addition, it can also induce the production of vasocortin, a vasoconstrictor substance. 3. Inhibit the expression of various cytokines, such as interleukin 1, 3, 4, 6, 8, tumor necrosis factor, granulocyte colony stimulating factor. Attenuate the role of the above factors in airway inflammation, especially chronic inflammation. 4. Promote the expression of adrenergic β2 receptors and improve the sensitivity to endogenous and exogenous medicinal β2 receptor agonists. 5. Immunosuppressive effect: It has an inhibitory effect on the entire immune process from the phagocytosis of antigens, the division, proliferation and differentiation of lymphocytes to the effector period. After budesonide is inhaled, it mainly inhibits the production of inflammatory sensitizing mediators and cytokines and other active substances in the airway and lung tissue through the combined effect of the above-mentioned links, shrinks the dilated mucosal blood vessels, and increases the stimulation of bronchial smooth muscle and inflammatory cells to β2. Drug sensitivity, etc., can have a good therapeutic effect on exogenous and endogenous asthma. In addition to relieving asthma, dyspnea and other clinical symptoms and improving pulmonary ventilation function, the anti-inflammatory effect of these drugs is more prominent than other asthma drugs. According to a group of long-term use of budesonide, bronchoscopy and tissue harvesting for histological examination before and after treatment found that budesonide can relieve or to a certain extent reverse the airway mucosal edema and subepithelial collagen deposition in patients with chronic asthma. Airway inflammatory remodeling lesions such as thickening. The anti-inflammatory effect of budesonide is about 500 times that of dexamethasone, so when microinhalation of budesonide produces the above local therapeutic effect, even if it is absorbed and swallowed through the airway (bioavailability is only 11%), it will not be effective. As for the obvious systemic glucocorticoid adverse reactions.