Factory Supply Pharmaceutical Raw Materials Dacarbazine CAS No. 4342-03-4 CAS NO.4342-03-4

Dacarbazine is a new type of purine precursor antineoplastic drug, which can interfere with the biosynthesis of purines and also act as an alkylating agent. It has inhibitory effect on mouse sarcoma-180, lung cancer-755, melanoma B16 and leukemia L-1210. It acts on the G2 phase of the cell cycle, mainly affecting RNA and protein synthesis, followed by DNA. Oral absorption is incomplete, and individual differences are large. After 1 intravenous injection, it reached a peak value within 30 minutes and disappeared. 30% of the dose was excreted in the urine in 6h. Cannot pass the blood-cerebrospinal fluid barrier. The citrate salt of dacarbazine, white crystalline powder, is mainly used clinically. The aqueous solution is highly acidic, with a pH of 1.9 to 2.3. Mainly used for malignant melanoma, better than hydroxyurea, such as combined with vinblastine, carmustine can improve the efficacy. Also used for lung squamous cell carcinoma and undifferentiated carcinoma, leiomyosarcoma, fibrosarcoma and so on. Ineffective for gastrointestinal tumors.

For disseminated malignant melanoma, the curative effect is better than other anticancer drugs. Single-agent therapy is most commonly used, but it can also be combined with BCG, transfer factor, and milfalan for immunochemical combination therapy. With (ABVD) and (MOPP), for some patients with advanced Hodgkin's disease with poor prognosis, alternate two kinds of combined chemotherapy can achieve long-term complete remission and even cure. It has a certain curative effect on various sarcomas, brain tumors, lung squamous cell carcinoma and small cell carcinoma, as well as childhood neuroblastoma.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.