Pharmaceutical intermediates Lower Price Fast Delivery CAS 2998-57-4 Estramustine CAS NO.2998-57-4

English name: Estramustine

CAS number: 2998-57-4

Molecular formula: C23H31Cl2NO3

Molecular weight: 440.4

EINECS Number: 221-076-3

Melting point: 104-105°

Specific rotation: D20+50°(indioxane)

Boiling point: 565.8±50.0°C (Predicted)

Density: 1.253±0.06g/cm3(Predicted)

Acidity coefficient: (pKa) 15.05±0.40 (Predicted)

Water solubility: 1mg/L (30ºC)

Estramustine, also known as cancer adenotherapy, is an antitumor drug synthesized from nitrogen mustard (HN2) and estradiol (E2), which binds to microtubule-associated proteins (MAP), and Dissociates MAP from tubulin, thereby inhibiting the assembly and depolymerization of microtubules, causing cells to arrest in metaphase, its entire molecule is an anti-mitotic agent, and after carbamate hydrolysis, metabolite-mediated release of estrogen exerts Antigonadotropin effect. Mild clinical side effects are due to the binding of estramustine to proteins in tumor tissue, resulting in accumulation of the drug at the target site. Estramustine also has mild estrogenic and antigonadotropic properties, and when administered orally, the absorption rate is about 75%. The metabolites estradiol and mechlorethamine can be found in bile, feces and urine. For the treatment of metastatic prostate cancer, especially hormone-resistant prostate cancer. Adverse reactions are nausea and sometimes intractable vomiting. Other less common adverse reactions are gynecomastia, nipple softening, and/or congestive heart failure exacerbated by mineralocorticoid effects in the steroidal portion of the molecular structure. Estramustine has been used in the clinical treatment of prostate cancer in recent years. At present, it is considered to be the drug of choice for prostate cancer that is not sensitive to hormone therapy. It can also improve the efficacy of surgery, radiation or other chemotherapy drugs in comprehensive treatment.

For advanced prostate cancer, especially in those who are hormone-refractory and who have been predicted to respond poorly to hormones alone in initial therapy

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.