Clotrimazole CAS 23593-75-1 Raw Material Pharmaceutical Chemicals CAS NO.23593-75-1

English name: Clotrimazole

CAS number: 23593-75-1

Molecular formula: C22H17ClN2

Molecular weight: 344.84

EINECS Number: 245-764-8

Melting point: 147-149°C

Boiling point: 501.14°C (rough estimate)

Density: 1.1095 (rough estimate)

Refractive index: 1.5940 (estimate)

Storage conditions: 2-8°C

Solubility:Soluble in chloroform,DMSO,DMF and alcohols

Form: neat

Acidity coefficient: (pKa)pKa4.7(EtOH50%aq)(Uncertain)

Water solubility: <10mg/L(25ºC)

Maximum wavelength: (λmax) 556nm (Phosphatebuffersol.) (lit.)

Merck: 14,2417

Clotrimazole is a synthetic pyrrole antifungal drug, which has inhibitory effect on a variety of pathogenic fungi, and can also have bactericidal effect at high concentrations. Clotrimazole inhibits the biosynthesis of fungal ergosterol and other sterols by interfering with the activity of cytochrome P450; it damages the fungal cell membrane and changes its permeability, resulting in the loss of important intracellular substances; it can also inhibit fungal triglycerides and phospholipids Biosynthesis; this product can still inhibit the activity of oxidation and peroxidase, causing excessive accumulation of peroxides in cells, resulting in degeneration and necrosis of fungal subcellular structures. Clotrimazole has broad-spectrum antifungal activity, and has good antibacterial effect on Epidermophyton, Trichophyton, Aspergillus, Chromophytes, Cryptococcus and Candida, and has good antibacterial effect on Sporothrix schenckii and Blastomyces dermatitis. , Coccidioides spp., Histoplasma spp. also have certain antibacterial activity. Clotrimazole has good bacteriostatic effect on Candida, Cryptococcus, Aspergillus, algae, dermatophytes, etc. in vivo and in vitro, and its efficacy on superficial skin mycosis is similar to that of griseofulvin. The efficacy of mycosis is similar to that of amphotericin B, and it has a good effect on visceral pathogenic fungi such as Candida albicans, Cryptococcus neoformans, Coccidioides and Histoplasma, etc. It has a better effect on Candida albicans than nystatin. powerful. Fungi are not easy to develop resistance to this product. This product is easily absorbed when taken orally, and can be taken orally to treat systemic and deep fungal infections, such as aspergillus fumigatosis, candidiasis albicans, cryptococcosis, coccidioidomycosis, histoplasmosis (dogs, cats) and fungal sepsis Wait. For severe deep fungal infections, it should be used in combination with amphotericin B. It can also be used externally to treat superficial fungal infections, such as cockscombs and tinea corporis and trichoderma in livestock. Ineffective for tinea capitis. Clotrimazole is also effective against some gram-positive bacteria and Trichomonas vaginalis.

1. Broad-spectrum antifungal drugs. For systemic fungal infections, also externally used for local fungal infections. 2. Antifungal drugs for the treatment of epidermal and deep fungal infections, etc.

Q1.Are you a manufacturer or a trading company
A1.Our company is a leading manufacturer specializing in trade and the development, production and marketing of pharmaceutical intermediates and apis for more than 10 years.
Q2.What about the quality of your products
A2.We value quality as life.We strictly control the quality of each process, established a perfect quality control system.
Q3.In the third quarter.What is your minimum order quantity
A3.Our minimum order quantity is 1 gram.
Q4.Fourth quarter.Can you provide free test samples
A4.Yes, we can provide 10g free samples for consumer test.
Q5.What is your delivery time
A5.Delivery takes 2-3 days, depending on the destination.
Q6.What about the mode of transportation
A6.For urgent and light orders, UPS, FedEx, DHL, EMS can be used;For heavier goods, we provide the method of air or sea transportation to consumers.
Q7.So far.How about the terms of payment
A7.We accept T/T,  Paypal, , money gram, etc.
 

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.