Pharmaceutical Chemical Factory Supply Esomeprazole Sodium CAS 161796-78-7 CAS NO.161796-78-7

Esomeprazole sodium is the sodium salt form of esomeprazole. It is a commonly used anti-ulcer drug. It was first successfully developed by AstraZeneca in Sweden. It is a proton pump inhibitor. The drug of choice for acid-related diseases such as ulcers and gastroesophageal reflux disease. At present, there are five PPIs commonly used in clinical practice: omeprazole, lansoprazole, rabeprazole, pantoprazole and esomeprazole. Omeprazole, as the first PPI drug, has been unanimously recognized for its efficacy in the treatment of acid-related diseases. Esomeprazole is the S-isomer of omeprazole, which reduces gastric acid secretion through a specific targeting mechanism and is a specific inhibitor of proton pumps in parietal cells. Due to its metabolic advantages, esomeprazole Compared with omeprazole, sodium azole has higher bioavailability and more consistent pharmacokinetics, which increases the amount of drugs reaching the proton pump, and is significantly better than lansoprazole, pantoprazole and radon in controlling gastric acid. Other proton pump inhibitors such as beprazole. In animal experiments, this product has a dose-dependent inhibitory effect on the activity of Na+/K+ ATPase on isolated rabbit gastric parietal cells, and its IC50 is 60μmol/L. The efficacy is greater than that of omeprazole (IC50 is 100μmol/L). At the same time, esomeprazole sodium can also inhibit the accumulation of 14C aminopyrine in isolated human gastric parietal cells caused by histamine, and the effect is twice as strong as omeprazole. Intravenous or enteral injection of esomeprazole sodium into the experimental ostomy rat model can inhibit the secretion of gastric acid caused by histamine, and its ED50 is 0.24 and 0.43 mg/kg, respectively. The ED50 of omeprazole administered by the same route were 0.30 and 0.68 mg/kg, respectively. Intestinal use of esomeprazole sodium in pylorus ligated rats can reduce the basal gastric acid secretion, and the effect is 3 times stronger than that of omeprazole. The drug can also prevent stress-induced or alcohol-induced gastric injury in experimental rats and has preventive and therapeutic effects on gastric injury caused by indomethacin and acetic acid, and its ED50 values ??are 1.6 and 5.5 mg/kg, respectively. It can be seen from the above experimental results that the efficacy of esomeprazole on ulcers is greater than that of omeprazole. In addition, there are experimental data showing that when esomeprazole sodium is combined with penicillin and clarithromycin, it can effectively treat duodenal ulcers and peptic ulcers caused by Helicobacter pylori infection

English name: Esomeprazole sodium

CAS number: 161796-78-7

Molecular formula: C34H36MgN6O6S2

Molecular weight: 713.12

EINECS Number: 620-470-6

Melt point: 156°C(approx)

Storage conditions: Inert atmosphere, Storeinfreezer, under-20°C

1. Treatment of acid-related diseases such as peptic ulcer and gastroesophageal reflux disease

2. Treats hypersecretion of gastric acid

Why choose KANAL:

1. quality
our products meet msds safe standard and we have iso and other certificate so you can get high quality products from our company.
2. price
we are the company which is the joint of trade and industry so we cao provide the competitive price and high quality product.
3.packing
we can do according to the customers' request.
4.transport
ems,dhl, tnt, ups ,fedex, by air, by sea
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sea shipping for quantity over 500kg; and air shipping is available for 50kg above;
for high value products, please select air shipping and dhl express for safe;
5.service
we offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes us able to offer you one-stop service from the order to the products transported to your hand.
we will try our best to satisfied you.
1. tailor-made for every customers. 
2. third-party test for the products you demand. 
3. test your counter-samples and produce them for you. 
4. best discount for old customers. 

1. We has 11 years' exporting experience in pharmaceutical ingredient products.

Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.