Lower Price High purity 99% factory price CAS 144701-48-4 Telmisartan CAS NO.144701-48-4

Use of Telmisartan

Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

Telmisartan (telmisartan), chemical name 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bis-1H-benzimidazole]-1'-yl) Methyl]-[1,1'-dibiphenyl]-2-carboxylic acid, molecular formula C33H30N4O2, is white or off-white crystalline powder, odorless and tasteless. It is soluble in chloroform, slightly soluble in dichloromethane or dimethylformamide, slightly soluble in methanol, very slightly soluble in ethanol, almost insoluble in water, and easily soluble in 1mol/L sodium hydroxide solution. Very slightly soluble in 0.1mol/L hydrochloric acid solution.
Molecular structure data
1. Molar refractive index: 154.51
2. Molar volume (cm/mol): 414.9
3. Isotonic specific volume (90.2K): 1096.2
4. Surface tension (dyne/cm): 48.7
5. Polarizability (10-24cm3): 61.25 [2]
Physical and chemical properties
Appearance and properties: white or off-white crystalline powder
Density: 1.16
Melting point: 261-263°C
Boiling point: 771.9ºC at 760mmHg
Flash point: 420.6ºC
Refractive index: 1.624
Water solubility: insoluble
Stability: Stable under normal temperature and pressure.
Storage conditions: Store in a cool, dry place (25ºC). The bottle should be kept tightly closed.
Vapor pressure: 0mmHg at 25°C

For the treatment of essential hypertension.
Non-peptide angiotensin II receptor antagonists can selectively and hardly reverse block ATI receptors without affecting other receptor systems. Used for mild to moderate hypertension. Telmisartan is a new type of blood pressure lowering drug, a specific angiotensin II receptor (AT) antagonist, used to treat essential hypertension. Substitute angiotensin II receptor and AT I receptor subtype (known angiotensin II action site) high-affinity binding. Telmisartan does not have any agonist effect at the AT receptor site, and selectively binds to the AT receptor, and the binding effect is long-lasting. It has no affinity for other receptors (including AT2 and other AT receptors with fewer features). The function of the above-mentioned other receptors is not yet known. As Telmisartan leads to an increase in the level of angiotensin II, the possible receptor overstimulation effect is also unknown. Telmisartan does not inhibit human plasma renin, nor does it block ion channels. It does not inhibit angiotensin-converting enzyme II, which can also degrade the adverse reactions caused by the enhanced bradykinin effect. In humans, 80 mg of telmisartan can almost completely inhibit the increase in blood pressure caused by angiotensin II. The inhibitory effect lasts for 24 hours and can still be measured at 48 hours. The antihypertensive effect is gradually obvious within 3 hours after the first dose. The maximum antihypertensive effect can be obtained 4 weeks after the start of treatment and can be maintained during long-term treatment. If the treatment is suddenly interrupted, the blood pressure gradually returns to the pre-treatment level after a few days without rebound hypertension. In a clinical trial study that directly compared two hypertension drugs, the incidence of dry cough in the treatment group was significantly lower than that in the angiotensin-converting enzyme inhibitor treatment group.

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1. We has 11 years' exporting experience in pharmaceutical ingredient products.

Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.