China (Mainland)
AZD-9291 CAS 1421373-65-0 Osimertinib CAS NO.1421373-65-0
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Keywords
- AZD-9291
- High Quality Osimertinib
- Factory Price AZD-9291
Quick Details
- ProName: AZD-9291 CAS 1421373-65-0 Osimertinib
- CasNo: 1421373-65-0
- Molecular Formula: C28H33N7O2
- Appearance: White to off-white powder
- Application: AZD9291 is an orally irreversible, sel...
- DeliveryTime: 3-7days
- PackAge: bag or barrel or drum
- Port: Shanghai or Shenzhen or Qingdao
- Purity: 99%+
- Storage: Store at room temperature
- Transportation: by express or air or sea
- LimitNum: 0
- Related Substances: <0.001%
- Residue on Ignition: <0.001%
- Valid Period: 2years
Superiority
As a third-generation EGFR inhibitor, osimertinib is aimed at the subgroup of patients with EGFR T790M mutation to meet such unmet market needs: osimertinib has high selectivity, and is highly selective for T790M/L858R mutation and exon 19 deletion of EGFR. The IC50s were 11.4 nM and 12.9 nM, respectively, while the inhibitory activity against wild-type EGFR (IC50) was 494 nM. Osimertinib is an irreversible inhibitor of EGFR and can form covalent bonds with molecular targets, so theoretically the response lasts longer and the chance of drug resistance is reduced accordingly.
Details
English name: AZD-9291
CAS number: 1421373-65-0
Molecular formula: C28H33N7O2
Molecular weight: 499.61
EINECS Number: 629-848-5
Melting point:>188oC(dec.)
Density: 1.19±0.1g/cm3(Predicted)
Storage conditions:Hygroscopic,-20°C Freezer,Under inert atmosphere
Dissolved: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
Acidity coefficient: (pKa) 12.68±0.70 (Predicted)
Form:Solid
Color: Pale Yellow to Beige
CAS number: 1421373-65-0
Molecular formula: C28H33N7O2
Molecular weight: 499.61
EINECS Number: 629-848-5
Melting point:>188oC(dec.)
Density: 1.19±0.1g/cm3(Predicted)
Storage conditions:Hygroscopic,-20°C Freezer,Under inert atmosphere
Dissolved: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
Acidity coefficient: (pKa) 12.68±0.70 (Predicted)
Form:Solid
Color: Pale Yellow to Beige