for Antibacerial 99% High Quality by HPLC Hot Sale! Factory Supply High Quality Rifampicin Raw Materials CAS 13292-46-1 CAS NO.13292-46-1

Product Name: Rifampicin
Synonyms: 9,17,19,21-hexahydroxy-23-methoxy-2,4,12,1///;2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2-h)-dione,5,6;3-(((4-methyl-1-piperazinyl)imino)methyl)-rifamyci;3-((4-methyl-1-piperazinyl)iminomethyl)rifamycinsv;8-(((4-methyl-1-piperazinyl)imino)methyl)rifamycinsv;8-(4-Methylpiperazinyliminomethyl)rifamycinSV;8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins
CAS: 13292-46-1
MF: C43H58N4O12
MW: 822.94
EINECS: 236-312-0
Melting point: 183°C (dec.)
Boiling point: 761.02°C
Storage temp.: 2-8°C

Description:

Rifampicin is a semisynthetic derivative of rifamicin B, a macrolactam antibiotic and one of more than five antibiotics from a mixture of rifamicins A, B, C, D, and E, which is called a rifamicin complex, which is produced by actinomycetes Streptomyces mediteranei (Nocardia mediteranei). It was introduced into medical practice in 1968. Synthesis of rifampicin begins with an aqueous solution of rifamicin, which under the reaction conditions is oxidized to a new derivative of rifamicin S, with the intermediate formation of rifamicin O. Reducing the quinone structure of this product with hydrogen using a palladium on carbon catalyst gives rifamicin SV. The resulting product undergoes aminomethylation by a mixture of formaldehyde and pyrro lidine, giving 3-pyrrolidinomethylrifamicin SV. Oxidizing the resulting product with lead tetracetate to an enamine and subsequent hydrolysis with an aqueous solution of ascorbic acid gives 3-formylrifamicin SV. Reacting this with 1-amino-4-methylpiperazine gives the desired rifampicin.

Usage:

Semisynthetic antibiotic. Antibacerial (tuberculostatic)

1. Broad-spectrum antibiotics. It has bacteriostatic or bactericidal effects on Mycobacterium tuberculosis, Gram-positive bacteria and some Gram-negative bacteria. It is mainly used for the infection of drug-resistant tuberculosis plant bacteria and drug-resistant Staphylococcus aureus, and also has a certain curative effect on leprosy.

2. It is a broad-spectrum antibiotic and can enter into cells. It is a full-effect bactericidal drug with strong bactericidal power.

3. It is a broad-spectrum antibiotic with strong bactericidal effect on Mycobacterium and Gram-positive and negative bacteria

4. Used as a pharmaceutical intermediate

5. Broad-spectrum antibiotics. It has bacteriostatic or bactericidal effects on Mycobacterium tuberculosis, Gram-positive bacteria and some Gram-negative bacteria. It is mainly used for the infection of drug-resistant tuberculosis plant bacteria and drug-resistant Staphylococcus aureus, and also has a certain curative effect on leprosy. It is a broad-spectrum antibiotic and can enter into cells. It is a full-effect bactericidal drug with strong bactericidal power. It has good antibacterial activity against Gram-positive cocci and Mycobacterium tuberculosis, and the antibacterial spectrum is the same as that of rifampicin

6. It has a broad-spectrum antibacterial effect, and has good antibacterial activity against Gram-positive cocci and Mycobacterium tuberculosis. The antibacterial spectrum is the same as that of rifampicin.

7. APIs (anti-tuberculosis antibiotics)

8. Inhibits DNA recombination and protein insertion into mature virus particles. Inhibits initiation of RNA synthesis by binding to the β-subunit of RNA polymerase.

Orange red flake crystal or brick red crystal powder. Decomposes at 183-188°C. Soluble in chloroform and dimethyl sulfoxide, soluble in ethyl acetate, methanol and tetrahydrofuran, soluble in water (pH<6), propanol and carbon tetrachloride. The dry powder can be stable for more than 5 years, and its aqueous solution fails at room temperature for 10 hours, but adding a reducing agent (such as ascorbic acid) can reduce the decomposition, and it is extremely stable in dimethyl sulfoxide.

1. We has 11 years' exporting experience in pharmaceutical ingredient products.

Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.