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Home > Products >  Safe Delivery 99% Purity ABT-199 CAS 1257044-40-8 Venetoclax

Safe Delivery 99% Purity ABT-199 CAS 1257044-40-8 Venetoclax CAS NO.1257044-40-8

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Keywords

  • ABT-199
  • Venetoclax
  • Bulk Price Venetoclax

Quick Details

  • ProName: Safe Delivery 99% Purity ABT-199 CAS 1...
  • CasNo: 1257044-40-8
  • Molecular Formula: C45H50ClN7O7S
  • Appearance: White powder
  • Application: ABT-199 is a new type of anti-cancer d...
  • DeliveryTime: 3-7days
  • PackAge: bag or barrel or drum
  • Port: Shanghai or Shenzhen or Qingdao
  • ProductionCapacity: 6000 Kilogram/Day
  • Purity: 99%+
  • Storage: Store at room temperature
  • Transportation: by express or air or sea
  • LimitNum: 1 Gram
  • Related Substances: <0.001%
  • Residue on Ignition: <0.001%
  • Valid Period: 2years
  • Assay: 99%+
  • Shelf Life: 2 years
  • Appearance: White Powder

Superiority

Product Name Venetoclax
Appearance White Power
CAS No. 1257044-40-8 
MF C45H50ClN7O7S

ABT-199 is a white powder, Venetoclax, also known as ABT-199 or GDC0199, ABT-199 is an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. ABT-199 mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells.
 

ABT-199 is a small molecule oral drug that treats chronic lymphocytic leukemia (CLL) in those with a specific chromosomal abnormality.In 2015, the United States Food and Drug Administration (FDA) granted Breakthrough Therapy Designation to venetoclax for subjects with CLL who have relapsed or have been refractory to previous treatment and have the 17p deletion genetic mutation.
ABT-199 is a white powder, Venetoclax, also known as ABT-199 or GDC0199, ABT-199 is an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. ABT-199 mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells.

ABT-199 is a new type of anti-cancer drug, a Bcl-2 inhibitor, developed by the American pharmaceutical company AbbVie, which can effectively prevent cancer, and will produce smaller than current drugs This study was mainly completed by researchers in the United States and Australia, and the relevant research results were published in the international journal NatureMedicine. Unlike common cancer drugs: The drug, named ABT-199, works by attacking an important protein called BCL-2. BCL-2 is one of the first members of the BCL-2 family of proteins discovered to regulate cell death. It is associated with many cancer types, as well as some psychiatric and autoimmune diseases. In cancer, it is thought to act as a suppressor that helps cancer cells resist cancer treatment drugs. In cancer treatment, cancer cells can use the pro-survival protein BCL-2 to suppress the therapeutic effects of traditional chemotherapy, often a headache for clinicians. It is precisely because cancer cells can use the pro-survival protein BCL-2 to inhibit the therapeutic effect of traditional chemotherapy, which makes clinicians have to repeatedly increase the dose, which leads to chemotherapy side effects such as nausea and hair loss. The emergence of ABT-199 as a drug that can eliminate and reduce BCL-2 in cancer cells has allowed many clinicians to see the dawn of cancer treatment. ABT-199, a novel anticancer drug, inhibits BCL-2 growth without affecting BCL-XL, a protein necessary for platelet formation. The overcoming of this problem is completely worthy of cheering in the history of tumor treatment.

Details

English name: ABT-199
CAS number: 1257044-40-8
Molecular formula: C45H50ClN7O7S
Molecular weight: 868.44
EINECS Number: 820-130-9
Melting point:>150°C(dec.)
Density: 1.340±0.06g/cm3(Predicted)
Storage conditions: -20°C Freezer
Solubility: DMSO(Slightly)
Form: Yellow solid.
Acidity coefficient: (pKa) 4.09±0.10 (Predicted)
Color:White

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.

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