Pharmaceutical Grade Vinorelbine Tartrate CAS 125317-39-7 CAS NO.125317-39-7

English name: Vinorelbine tartrate

CAS number: 125317-39-7

Molecular formula: C53H66N4O20

Molecular weight: 1079.11

EINECS Number: 639-264-2

Melting point: 181-183°C

Storage conditions: 2-8°C

Solubility:H2O: 10 mg/mL

Form: powder

Color: off-white

Stability:Light Sensitive, Temperature Sensitive

Vinorelbine is a derivative of vinblastine, and its effect is similar to that of vincristine. It was first launched in France in 1989. The main role is to bind to tubulin, thereby hindering the formation of microtubules in cells during mitosis. Vinorelbine is a cycle-specific drug, which is commonly used clinically for the treatment of non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, head and neck phosphorus cancer, leukemia, as well as small cell lung cancer, colon cancer, brain tumor, and malignant melanoma. etc. also have a strong inhibitory effect.

Vinorelbine tartrate is the tartrate form of vinorelbine, a semi-synthetic vinblastine compound, which is a M-phase specific drug, and its mechanism of action is similar to that of vincristine. Mainly by selectively blocking tubulin polymerization in mitotic cells to form microtubules, which can induce tubulin depolymerization, hinder the spindle microtubules, stop cell division in the middle stage, and affect the tubulin synthesis of neuronal axons. very little. Due to the poor affinity of NVB for axonal microtubules and its effect on axons only at high concentrations, neurotoxicity is lower than other vinblastine drugs and has a larger therapeutic index. The human pharmacokinetic study of vinorelbine shows that after intravenous administration, it is a three-compartment model, with a large volume of distribution, PPB can reach 50% to 80%, and the plasma clearance rate is high. The terminal clearance phase T1/2 is 40h, and the tissue The distribution was faster, and the concentration in tissues was significantly higher than that of vincristine (VCR) and vindesine (VDS). The plasma clearance rate is 0.8L/(kg·h), mainly secreted by the biliary tract and excreted with the feces, and the urinary excretion accounts for 10% to 15%. Higher efficacy and less adverse reactions to the nervous system.

1. Pyridone broad-spectrum antifungal drugs have inhibitory effect on a variety of skin fungi. The substances necessary for the survival of Candida albicans cells, such as amino acids, potassium ions, and phosphates, can be prevented from passing through the cell membrane to cause the exhaustion of some important substrates or ions in the cells, thereby inhibiting or killing the fungal cells. It has a wide range of antifungal effects, and has a killing effect on skin filamentous bacteria, yeast fungi, and a variety of Gram-positive and negative bacteria, Chlamydia, Trichomonas, Proteus, Escherichia coli, Pseudomonas and Staphylococcus aureus. Bacteria, etc. have inhibitory effect. It is commonly used in the treatment of dermatophytosis, tinea versicolor, vulvovaginal candidiasis, skin and finger (toe) nail candidiasis, etc., with significant curative effect and low side effects.

2.Ciclopirox is a synthetic antifungal drug.

Q1.Are you a manufacturer or a trading company
A1.Our company is a leading manufacturer specializing in trade and the development, production and marketing of pharmaceutical intermediates and apis for more than 10 years.
Q2.What about the quality of your products
A2.We value quality as life.We strictly control the quality of each process, established a perfect quality control system.
Q3.In the third quarter.What is your minimum order quantity
A3.Our minimum order quantity is 1 gram.
Q4.Fourth quarter.Can you provide free test samples
A4.Yes, we can provide 10g free samples for consumer test.
Q5.What is your delivery time
A5.Delivery takes 2-3 days, depending on the destination.
Q6.What about the mode of transportation
A6.For urgent and light orders, UPS, FedEx, DHL, EMS can be used;For heavier goods, we provide the method of air or sea transportation to consumers.
Q7.So far.How about the terms of payment
A7.We accept T/T,  Paypal, , money gram, etc.
 

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.