High Purity DM1-SMCC CAS 1228105-51-8 in stock CAS NO.1228105-51-8

English name: DM1-SMCC

CAS number: 1228105-51-8

Molecular formula: C51H66ClN5O16S

Molecular weight: 1072.61

Melting point:>166°C(dec.)

Density: 1.41±0.1g/cm3(Predicted)

Storage conditions: -20°C Freezer

Solubility: Chloroform(Slightly), Methanol(Slightly)

Acidity coefficient: (pKa) 9.82±0.70 (Predicted)

Form:Solid

Color: White to Off-White

The antitumor effects of mouse/human chimeric CD138-specific monoclonal antibody nBT062 and highly cytotoxic maytansinoid derivatives on multiple myeloma (MM) cells were investigated in vitro and in vivo. The in vivo activity of BT062SPDB-DM4, BT062-SMCC-DM1 and BT062-SPP-DM was examined in a mouse MM cell xenograft model in humans and severe combined immunodeficiency (SCID) mice with injection of human MM Implantation of cells (SCID) on a bone chip-hu model). The in vivo efficacy of nBT062-SPDB-DM4, nBT062-SMCC-DM1 and nBT062-SPP-DM1 was next evaluated in SCID mice bearing established CD138 positive MOLP-8 human MM cells. Administration of a single intravenous injection of the immunoconjugate resulted in significant dose-dependent tumor growth inhibition and tumor regression at well-tolerated concentrations, as evidenced by stable body weights. nBT062SPDB-DM4 was the most active conjugate tested in this model. In addition, weekly administration of nBT062-SMCC-DM1 (six doses of 13.8 μg/kg) completely blocked tumor growth during the dosing period. Taken together, nBT062-SMCC-DM1, nBT062-SPDB-DM4, and nBT062-SPP-DM1 have antitumor activity against CD138-positive MM cells in vitro and in vivo, and can overcome the protective effects of cytokines and BMSCsClinCancerRes.1, We offer competitive factory price for both wholesalers and retailers.
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3, Stable Quality, high purity.
4, We offer EXW/FOB/CFR/DAP/DDP trade terms for your option.
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English name: DM1-SMCC
CAS number: 1228105-51-8
Molecular formula: C51H66ClN5O16S
Molecular weight: 1072.61
Melting point:>166°C(dec.)
Density: 1.41±0.1g/cm3(Predicted)
Storage conditions :-20°C Freezer
Solubility: Chloroform(Slightly), Methanol(Slightly)
Acidity coefficient: (pKa)9.82±0.70(Predicted)
Form :Solid
Color :WhitetoOff-White

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.