99% Raw Material MC-Val-Cit-PAB-MMAE MC-VC-PAB-MMAE VcMMAE Vc-Mmae CAS No. 646502-53-6 CAS NO.646502-53-6

English name: VcMMAE

CAS number: 646502-53-6

Molecular formula: C68H105N11O15

Molecular weight: 1316.63

Boiling point: 1347.6±65.0°C (Predicted)

Density: 1.196±0.06g/cm3(Predicted)

Storage conditions: Sealed in dry, RoomTemperature

Acidity coefficient: (pKa) 13.29±0.70 (Predicted)

VcMMAE (mc-vc-PAB-MMAE) is a biochemical reagent that is part of an antibody drug complex (drug-linker conjugate for ADC) with anticancer activity, which is linked by MMAE (a tubulin inhibitor) and Vc made. VcMMAE (mc-vc-PAB-MMAE) is a drug-linker conjugate of ADC through the use of the anti-mitotic agent monomethyl auristatin E (MMAE, a tubulin inhibitor), a dipeptide cleavable by the lysosome, Valine-citrulline (vc).

Binding of monomethyl auristatin E (MMAE) to IR resulted in delayed tumor growth, and ACPP-cRGD-MMAE targeting tumors with IR produced more stable and significantly prolonged tumor regression in xenograft models.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.