Antihypertensive CAS 63675-72-9 Nisoldipine Raw Powder Nisoldipine Powder Pharmaceutical Nisoldipine CAS NO.63675-72-9

Nisoldipin is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.

Application:

1.Nisoldipine is used alone or together with other medicines to treat high blood pressure.
2.Nisoldipine, a calcium antagonist called dihydropyridine. It has a specific blocking effect on the calcium channel of smooth muscle and myocardium, which can make the peripheral blood vessels dilate and the resistance drop, thus lowering the blood pressure. It can also increase coronary blood flow and improve blood flow, which is stronger and longer than nifedipine and has almost no negative myodynamic effect.

Nisoldipine, Nimodipine, Nicardipine and Nitrendipine are four commonly used dihydropyridine calcium antagonists. Calcium antagonists are also known as calcium blockers, slow channel blockers and calcium channel blockers. Antiarrhythmic drugs are a general term for a class of drugs that inhibit the activation of calcium ion channels and reduce the influx of calcium ions. Nisoldipine, also known as nifedipine, Dexinting, Nielxin, Yili, Nili, and Diyixin, is the most powerful calcium antagonist. It was successfully developed by Bayer Pharmaceuticals in Germany for the first time. It has a high degree of selectivity, and its activity on blood vessels is 3 to 5 times that of other tissues. It can significantly reduce peripheral vascular resistance and myocardial oxygen consumption, increase coronary blood flow, improve perfusion in ischemic areas, and improve myocardial resistance to ischemia. Receptivity, and significantly reduce the proportion of myocardial low-irrigation area necrosis after coronary occlusion, expand peripheral arteries, reduce peripheral resistance and cardiac afterload, increase cardiac output and cardiac index, relieve coronary spasm, and improve left ventricular function , prevention of fatal ventricular fibrillation, and at the same time has obvious and lasting antihypertensive effect. Minimal effect on heart rate and myocardial contractility.

1. Clinically used for various types of angina pectoris, hypertension and congestive heart failure, especially for patients with diabetes

2. Dihydropyridine calcium antagonists. For hypertension, heart failure, ischemic heart disease, angina pectoris, atypical angina pectoris, especially suitable for coronary heart disease with hypertension.

3. Strong calcium antagonists for the treatment of hypertension complicated with coronary heart disease, hypertension and mild heart failure

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.