ISO Certified Reference Material High Quality Promestriene Powder CAS 39219-28-8 CAS NO.39219-28-8

Promestriene is a kind of special estradiol diether with its special molecular structure making it cause the biological effects in situ without the necessity of exerting the effect after being metabolized. It has a biological half-life of being smaller than 24 h. Therefore, upon vaginal administration, drug will directly take effect on the vaginal mucosa without being absorbed by the mucosa. There is no accumulation of estrogen in the body, particularly in the estrogen-sensitive organs far away from the vagina.
Clinical observation further noted that the topical administration of promestriene has no effect on the plasma sex hormone binding globulin (SHBG), estrone (E1), estradiol (E2), estriol (E3), LH and FSH, and can effectively prevent and treat the atrophic vaginitis with strict local estrogen effect.

Prostriene, Gengbaofen (Prostriene Soft Capsules and Creams) and Kebojing (Chloroquinado/Prostriene Vaginal Tablets) have been collected by the Martindale Drug Manual and have been clinically used in more than 40 countries abroad for 40 years. For more than a few years, it is still the first-line drug for the treatment of vaginal infection and atrophic vaginitis in many countries. Clinical practice shows that it is safe and effective, and the patients are well tolerated. Promestriene is a special estradiol diether, and its special molecular structure enables it to have biological effects in situ without metabolism, and its biological half-life is less than 24h. Therefore, for vaginal administration, the drug directly acts on the vaginal mucosa and is not absorbed by the mucosal tissue, and estrogen does not accumulate in the body, especially in the estrogen-sensitive organs far away from the vagina. The clinical observation further pointed out that the topical use of proestene has no effect on plasma sex hormone binding protein (SHBG), estrone (E1), estradiol (E2), estriol (E3), LH, and FSH, and can effectively Prevention and treatment of atrophic tract inflammation with strict local estrogenic action. Compared with other drugs, the advantage of prostriene is that it is hardly absorbed through the vagina, so it can effectively avoid the systemic risks brought about by long-term vaginal local estrogen supplementation, and there are fewer adverse reactions, and it is less severe and has no systemic effects. It has mild side effects and high safety. Most patients are willing to accept it. It is a good choice for the current treatment of atrophic vaginitis, especially for those patients with estrogen-dependent diseases.

This product is a chemically synthesized steroid estrogen. It mainly acts on the vaginal mucosa locally. It thickens the mucosa, balances the pH of the vagina, improves the vaginal environment, enhances the resistance of vaginal tissues, reduces vaginal infection, and has a good effect on improving atrophy. The role of local symptoms of vulvar and vaginal vaginitis, which produces local estrogenic effects on the mucosa at the bottom of the female genital tract. This product is topical and does not produce systemic estrogenic effects on organs remote from the vagina after intravaginal use.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
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Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.