Buy Ezetimibe CAS: 163222-33-1 with Best Price on Line CAS NO.163222-33-1

1, We offer competitive factory price for both wholesalers and retailers.
2, Fast reply for inquiries.
3, Stable Quality, high purity.
4, We offer EXW/FOB/CFR/DAP/DDP trade terms for your option.
5, Fast Delivery for shipment and Safe for destination custom clearance.
6, Free samples.
7, Free custom clearance with freight prepaid, delivery door to door.
8, More than 22 years export experience in this field.

Ezetimibe is a white crystalline powder, easily soluble in ethanol, methanol and acetone, insoluble in water, with a melting point of about 163°C and stable at room temperature. Ezetimibe only acts on the small intestine, reducing the transport of intestinal cholesterol to the liver by inhibiting the absorption of cholesterol, reducing its storage; it can enhance the clearance of cholesterol in the blood, thereby reducing plasma cholesterol levels

After oral absorption, ezetimibe combines with glucuronide to form the active substance, ezetimibe-glucuronide, which is excreted through bile and kidney. After oral administration, the peak plasma concentration is reached within 4 to 12 hours, the Cmax is 3.4 to 5.5 mg/mL, the bioavailability is between 35% and 60%, and the t1/2 is about 22 hours. Ezetimibe mainly acts on exogenous cholesterol, while the main effect of statins is to reduce the synthesis of cholesterol in the liver, so the two drugs have a synergistic effect. The combined use of ezetimibe and statin hypolipidemic drugs produced 8 times the cholesterol-lowering effect of statin alone.

Ezetimibe is a new class of selective cholesterol absorption inhibitors, by binding to the membrane protein (relative molecular weight 145X103) on the small intestinal brush border membrane vesicles, inhibiting the small intestine's effect on diet and bile transport into the intestine absorption of cholesterol, reducing serum and liver cholesterol levels.

Hyperlipidemia is one of the high-risk factors for coronary heart disease. The drugs for clinical treatment of hyperlipidemia mainly include cholesterol synthesis inhibitors (such as statins), phenoxy acids (such as fibrates), and bile acid chelators (such as cholestyramine) and others (such as niacin analogs), etc.

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together.  Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.


1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions. 
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world