Pharmaceutical intermediates Chemical Powder Antihypertensive Drug CAS 137862-53-4 Valsartan CAS NO.137862-53-4

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Valsartan is an antihypertensive drug with angiotensin II receptor antagonist. The drug can block the angiotensin 2 type I (AT1) receptor, increase the angiotensin na-plasma level, stimulate the unblocked AT2 receptor, and counteract the effect of AT1 receptor, so as to achieve the effect of dilating blood vessels and reducing blood pressure.
Valsartan is a drug used in the United States for the treatment of hypertension, congestive heart failure, and post-myocardial infarction.

English name: Valsartan CAS number: 137862-53-4 Molecular formula: C24H29N5O3 Molecular weight: 435.52 EINECS Number: 1592732-453-0 Melting point: 116-117°C Boiling point: 684.9±65.0°C (Predicted) Density: 1.212±0.06g/cm3(Predicted) Storage conditions: 2-8°C Solubility: DMSO: ≥20mg/mL Acidity coefficient: (pKa) 3.56±0.10 (Predicted) Form: powder Color: white to tan Optical activity: (opticalactivity)[α]/D-55to-70°,c=1inmethanol Water solubility: 84.99mg/L (25ºC) Merck: 14,9916 Stability: Hygroscopic

Valsartan is a specific angiotensin II (AT1) receptor antagonist, and it is another non-skin AT1 receptor antagonist used in clinic after losartan. It can regulate systemic blood pressure and maintain electrolyte and body fluids. Balance plays a key role. It selectively acts on the AT1 receptor subtype and blocks the binding of Ang II to the AT1 receptor (its specific antagonism of the AT1 receptor is about 20,000 times greater than that of the AT2 receptor), thereby inhibiting vasoconstriction and the release of aldosterone, resulting in Antihypertensive effect, but does not inhibit potassium ion (K+)-induced aldosterone release. The antihypertensive effect is better than that of enalapril, and it is suitable for the treatment of anti-hypertension, mild to moderate primary hypertension, especially for secondary hypertension caused by kidney damage, which can significantly reduce the high blood pressure associated with diabetes or normal renal function. Proteinuria in patients with blood pressure, and has the renal protective effect of promoting the excretion of uric acid and urinary sodium. Also indicated to reduce cardiovascular mortality in high-risk patients (left ventricular failure or left ventricular dysfunction) following a heart attack. A clinical trial showed that valsartan was very effective in mild to moderate hypertension.

Crystallized from diisopropyl ether, the melting point is 116--117 °C. Antihypertensive drugs. Non-peptide angiotensin II AT1-receptor antagonist. Used to treat high blood pressure.

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